Marka laga hadlayo infakshanka aan la garanaynin ama infekshannada isku dhafan (maadiga, fangaska), daroogooyinka leh qaabka ugu ballaaran ee firfircooni waa muhiim. 5-NOC waa walxo adag oo ka hortag ah oo ka soo horjeeda sumeyntii ugu caansan. Waxay waxtar u leedahay qaar ka mid ah macallimiinta.
5-NOC - ka kooban
Maaddooyinka ugu muhiimsan ee daroogada ee su'aasha waa nitroxolin. Waa bir kiimiko ah oo ka sameysan kiimikada 8-hydroxyquinoline, waxay ka hortagtaa unugyada DNA-da ee unugyada pathogenic waxayna ka hortagaan dhalmada. Qaybaha waxqabadka ee ku jira shaxda 5-NOC-kiniiniga waxaa ka mid ah:
- lactose monohydrate;
- phosphate hydroxide kalsiyum;
- burjiga galleyda;
- Povidone K25;
- silicon dioxide Colloidal;
- nadiifinta talc;
- magnesium stearate;
- kiniiniyada.
Kiniinnada waxaa lagu soo saaraa qolka ilaalinta, taas oo ka kooban maaddooyinka soo socda:
- sodium carmellose;
- acacia gum;
- silicon dioxide Colloidal;
- Povidone K25;
- titanium dioxide;
- burjiga galleyda;
- sukrose;
- nadiifinta talc;
- kalsiumam carbonate;
- midabada cuntada - jaalaha "Sunset Sunset" (E110) iyo quinoline (E104).
5-NOC - tilmaamid
Daawada waxaa loogu talagalay daaweynta infakshannada ba'an ama gaabis ah ee cudurrada kaadida iyo taranka. Kiniinada 5-NOC waxay wax ku oolayaan kooxaha noocyada jeermiska:
- Gawaarida wanaagsan ee aerobic iyo anaerobic;
- aerobic-gram-negative iyo anaerobic;
- mycoplasma ;
- hingaplasma ;
- Trichomonas;
- Qaaxada Mycobacterium;
- dermatophytes;
- fangaska caaga ah;
- musharaxa;
- dareen-celiyeyaasha xanuujinaya aalkolada qoto dheer iyo daran.
5-NOC - calaamadaha loo isticmaalo:
- cystitis;
- pyelonephritis ;
- epididimitis;
- dhuunta;
- buro cudurka qaba (adenoma, carcinoma) ee prostate;
- prostatit;
- geedi socodka bararka kaadiheysta ee kaadiheysta ama socodka.
Diyaargarowga lagu sharaxay waxaa loo isticmaalaa in looga hortago caabuqyada xaaladaha noocaas ah:
- muddada postoperative;
- Hawlgallada baadhista;
- cystoscopy ;
- tuubada.
5-NOC - waxyeelooyinka dhinaca
Daawada lidka ku ah bakteeriyada adag waxay dhalin kartaa diidmo diidmo ah oo jirka ka yimaada nidaam kasta. Taas macnaheedu waa marar dhif ah ayay keenaysaa dhibaatooyinka soo raaca. Xaaladaha aan caadiga ahayn, diyaarinta 5-NOC waxay keeneysaa:
- tachycardia;
- matag;
- anorexia;
- lallabbo;
- hawlaha beerka oo daciif ah;
- dawakhaad;
- optic neuritis (oo leh naqshad joogto ah);
- sharaxaadda;
- la'aanta isuduwid la'aan;
- madax xanuun;
- polyneuropathy;
- trombocytopenia;
- kororka xajinta uric acid;
- urtikaria;
- cuncunka maqaarka;
- Ataxia;
- kaadida kaadida midab huruud ah.
5-NOC contraindications
Qalabkan laguma talineynin shakhsiyaadka aan loo dulqaadan karin mid ka mid ah maaddooyinka kor lagu taxay, oo ay ku jiraan xeryahooda kiimikada ah iyo qaybaha qolofka. Daroogada 5-NOC waa lagama-maarmaan xaaladahan:
- uurka;
- cataract;
- naas-nuujinta;
- carqaladda daran ee beerka ama kelyaha oo leh nadiifin sameinine ah oo ka yar 20 ml / min (oo loo qorey si dhif ah, taxadar leh);
- da'da 3 sano.
Sidee loo qaataa kiniinada 5-NOC?
Qaybta maalinlaha ah ee daaweynta waxay ku xiran tahay da'da iyo jiritaanka cudurrada daba-dheeraadka ah. Dadka qaangaarka ah maalintii waxay u baahan yihiin 400 mg daroogada 5-NOC - codsigu wuxuu ku lug leeyahay qaadashada qiyaastaas, oo loo qaybiyay 4 jeer, 100 mg (2 kiniin) ka hor cuntada. Iyada oo leh bakteeriyo xoog leh, qaybta ayaa labanlaaban (800 mg). Carruurta da'doodu ka weyn tahay 5 sano jir ayaa loo qoraa 200-400 mg daawo 24-kii saacadoodba, iyo carruurta 3-5 sano jir ah - 200 mg. Koorsada guud ee daaweynta kama badna 2-4 asbuuc, haddii loo baahdo, ku celi.
5-NOC-ga waxaa loo isticmaalaa taxadarka ugu sareeya - calaamadaha loo adeegsado kuma jiraan cuduradan, laakiin cudurada halista ah, antibiyootig ayaa loo qori karaa. Xaaladahaas, qaado 1 kiniin 4 jeer maalintii. Waa lagama maarmaan in si joogta ah loola socdo jawaab celinta kelyaha iyo beerka si loo daweeyo loona ilaaliyo heerka nadiifinta abuurka.
5-NOC - codsi loogu talagalay cystitiska
Qiyaasta daawada antimicrobial waxay u dhigantaa qiyaasta caadiga ah ee 400 mg nitroxiin kasta 24 saacadood kasta. 5-NOC oo leh cystitis ayaa lagu taliyaa inta lagu jiro 10-21 maalmood. Muddada saxda ah ee daaweynta waxaa lagu xisaabiyaa aqoonyahan ku takhasusay cilmi-baarista shaybaarka, darnaanta geedi-socodka bararka, iyo joogitaanka saameynta daaweynta. Mararka qaarkood waa in la dheereeyaa ilaa 1 bilood, gaar ahaan haddii infekshanka la isku daro ama labaad.
5-NOC oo leh cudurka pyelonephritis
Jirrada la sharraxay ee qaabka degdega ah waxay u baahan tahay koorso gaaban oo daaweynta antibiyootigga caadiga ah, 400 mg maalintii oo ah 2-2.5 usbuuc. Xaaladda joogtada ah ee pyelonephritis soo noqnoqda, dhakhtarka kaadiheysta wuxuu go'aaminayaa sida loo qaato 5-NOC. Waxaa jira nidaamyo daaweyn muddo dheer ah (2-3 bilood 14 maalmood) iyo noocyo kala duwan oo loo isticmaalo daawada qadar yar (100-200mg).
Mararka qaarkood waxay qaadataa saldhigga ugu dheer ee 5-NOC - calaamadaha loo isticmaalo waxaa ka mid ah noocyada halista ah ee pyelonephritis:
- xanthogranulomatous;
- nadiif;
- qiyaasta.
5-NOC ee uurka
Inta lagu jiro xilliga geedka, habka haweenka ee haweenka ayaa aad u nugul waana ay u nugul yihiin geeddi-socodka nabarrada. Sidaa darted, hooyooyinka uurka leh waxay badanaa xiiseynayaan 5-NOC - ma cabbi karaa inta lagu guda jiro uurka iyo qadarkeeda. Daawada antibiyootiggu waxay ka hortageysaa xaaladdan, sababtoo ah waxay si xun u saamayn kartaa horumarka ama sameynta uur-jiifka.
5-NOC-analogues
Marka daawada antimicrobial ee aan la isticmaali karin ama ay ka dhalan karto dhibaatooyinka halista ah, waa in la kansal gareeyo. Habka keliya ee lagu beddeli karo kiniinada 5-NOC waa iyada oo la adeegsanayo isku mid ah isku midka ah ama jilicsanaanta. Waxaa jira laba nooc oo toos ah oo loo isticmaalo daroogada lagu sharaxay:
- Nitroxolin (Jarmal, Ruush);
- Uroksolin (Ukraine).
Daawada ugu horreysa waxaa lagu soo saaraa xoogaa kala duwan oo ah qaybo firfircoon, taas oo ku haboon daaweynta qiyaasta sare. Daawada labaad waxay ku jirtaa kiniiniyada oo leh walax kiimiko ah oo firfircoon oo 50 mg ah. Haddii aan loo dulqaadan karin nitroxolin ama waxyaalaheeda deriska ah, waa lagama maarmaan in la isticmaalo guud ahaan. Daroogadaasi waxay leedahay astaamo la mid ah 5-NOC - calaamadaha ugu muhiimsan ee isticmaalka, waxqabadka bakteeriyada iyo antifungal, laakiin waa nooc ka duwan. Daawooyinka wax ku oolka ah waxaa lagu soo bandhigaa qaabka bakteeriyada:
- Dareemaha dabaysha;
- xiidmaha;
- haddii;
- staphylococcal;
- Protein;
- Klebsiella Pneumonia;
- Pseudomonas (pseudomonas);
- kolik-proteyny;
- salmonella.
Noocyada kale ee leh calaamadaha isku midka ah:
- Fosmicin;
- Ureacid;
- Fosmural;
- Bernie;
- Fosmicin;
- Monural;
- Phosphoral;
- Urofosfabool;
- Dhuumaalnimada;
- Xilligan;
- Urofoscin;
- Phosphocin;
- Espa-Focine.