17-OH progesterone ama 17-hydroxyprogesterone waa hormoon steroid ah oo lagu soo saaro walxaha kortikal ee qanjirrada adrenal oo ah hormuudka hormoonada sida cortisol, estradiol iyo testosterone. Waxaa sidoo kale laga soo saaraa qanjidhada jinsiga, baaluqa baaluqa, jidhka jaalaha ah iyo mandheerta iyo saameynta enzyme 17-20 lyase wuxuu isu beddelaa hormoonada jinsiga. Marka xigta, waxaan tixgelin doonaa doorka 17-progesterone ah ee haweenka aan uurka lahayn iyo uurka iyo calaamadaha korodhka iyo kobaca.
Noocyada bayoolojiga ee hormoonka 17-oh progesterone
Heerka qof walba oo ah 17-OH progesterone wuxuu ku dhacaa 24 saac gudahood. Sidaa darteed, fiirsashada ugu sareysa ayaa la xusay saacadaha subaxda, iyo ugu yaraan - habeenkii. 17-OH progesterone dumarka way kala duwan yihiin waxayna ku xiran tahay wajiga wareegga caadada. Xaddiga ugu sarreeya ee heerkan ee hormoonkan ayaa lagu xusay habeenka ugxanta (kahor kordhinta ugu badan ee hormoonka luteining). 17-OH progesterone ee heerka wajiga ayaa si deg deg ah hoos ugu dhacaya, gaaraya heerka ugu hooseeya ee wajiga ugxan-la'aanta.
Hadda ka fiirso qiimaha caadiga ah ee 17-OH progesterone, iyadoo ku xidhan wajiga wareegga caadada:
- ee wajiga luteal - 0.99-11.51 nmol / l;
- heerka wajiga - 1,24-8,24 nmol / l;
- ee wajiga ugxanta - 0,91-4,24 nmol / l.
17-OH progesterone ee uurku wuxuu kordhay, gaarista qiimaha ugu sarreeya toddobaadyadii la soo dhaafay. Xilliga uurka, mandheerta waxaa kale oo ay ka jawaabtaa suurtogalnimada hormoonka steroid this. Ka fikir qiimaha la oggol yahay ee 17-OH progesterone inta uurka la joogo:
- saddexda bilood ee hore - 3,55-17,03 nmol / l;
- ee saddexda bilood ee labaad - 3,55-20 nmol / l;
- saddexda bilood ee saddexaad - 3.75-33.33 nmol / l.
Waqtiga premenopausal iyo waqtiga menopause, heerka hormoonka 17-OH progesterone hoos buu u dhacaa oo gaari karaa 0.39-1.55 nmol / l.
Isbeddelka heerka 17-OH progesterone - ogaanshaha iyo calaamadaha
Heerka 17-OH ee progesterone ee ku jira dhiigga ayaa badanaa keena keena adrenal hypoplasia waxaana lagu dhejin karaa wax soo saar dheeri ah ee hoormoonka kale. Xaalad ahaan, waxay u muuqan kartaa qaabka Cudurka Addison, iyo wiilasha horumarinta xubnaha taranka dibadda.
Kordhinta 17-OH progesterone sida caadiga ah waxaa lagu arki karaa oo kaliya marka ay uur leedahay, xaaladaha kale waxay muujinaysaa baaritaan. Sidaas darteed, progesterone sare 17-OH wuxuu noqon karaa calaamad muujinaysa burooyinka adrenal, ugxan-yaryaha (qaababka malignant and polycystosis) iyo jirrooyinka hidda-socodka ee kortens adrenal.
Xaalad ahaan, kororka 17-OH progesterone waxaa laga yaabaa in la muujiyo:
- Ku xadgudubka caadada;
- dhalmo la'aanta;
- abortions xaddidan;
- dhalasho ama geeridii hore ee dhallaanka;
- kororka progesterone 17-OH waxaa laga yaabaa in lagu arko finan (finan);
- Haddii 17-OH progesterone ay sare u kacdo, testosterone ayaa sidoo kale la kordhin karaa. Tan waxaa lagu muujin karaa qaab korodhka koraya ee timaha iyo wajiga (nooca timaha).
Heerka 17-OH progesterone ayaa lagu ogaan karaa iyadoo la baarayo serum
Sidaa daraadeed, waxaan baarnay doorka bayoolojiga ah ee jirka ee hormoonada hormoonka 17-OH iyo hormoonada la oggol yahay ee haweenka. Hoos udhaca heerka hoormoonkan wuxuu caadi ahaan noqon karaa keliya xilliga menopause, korodhkeedana waxaa loo tixgeliyaa caadi ahaan uurka oo dhan. Isbedelka heerarka 17-OH progesterone ee xaaladaha kale waxay noqon kartaa mid ka mid ah calaamadaha cudurka adrenal iyo ugxan-sidaha, taas oo keenta hyperandrogenism, dhalmo la'aanta ama ilmo soo ridid aan caadi ahayn.