Beta-blockers waxaa lagu magacaabaa daroogo si ku-meel-gaadh ah u xakameyn kara qabatimayaasha beta-adrenergic. Lacagahan waxaa inta badan lagu meeleeyaa marka:
- daweynta qalalka wadnaha;
- baahida loo qabo in laga hortago xanuunka miyoogada ee soo noqnoqda;
- daaweynta dhiig-karka.
Maxay tahay dukaamada beta-adrenergic?
Receptors-ka Beta-adrenergic waa soo-qabayaasha kuwaas oo ka falceliya hormoonnada adrenaline iyo noradrenaline waxayna u qaybsan yihiin saddex kooxood:
- β1 - inta badan waxay ku badan yihiin wadnaha, iyo kicinta waxaa ku jira korodhka xoogga iyo inta jeer ee qallalka ee wadnaha, cadaadiska dhiiggu kor u kaco; sidoo kale xayawaannada β1-adrenergic ayaa ku jira kelyaha waxayna u adeegaan sidii soo dhaweeyayaasha qalabka u dhow lobe;
- β2 - qaboojiyeyaasha, kuwaas oo laga helo bronchioles waxayna kicinayaan ballaarintooda iyo tirtiridda bronchospasm; Sidoo kale kuwa soo dhaweeyayaashu waxay ku jiraan unugyada cagaarshowga, iyo kicinta ay hormoonyadu waxay kor u qaadayaan kala-goyska glycogen (polysaccharide reserve) iyo sii daaya glucoseka dhiigga;
- Qaybta 3-aad ee loo yaqaan 'adipose nerve', oo saameyn ku leh hormoonnada ayaa xoojiya xakamaynta dufanka, waxay keenaysaa tamar sii deynta iyo kororka wax soo saarka kuleylka.
Qeybinta iyo liiska daroogada beta-blockers
Iyadoo ay ku xiran tahay xayaysiinaha ay saameynayaan beta-blockers, taas oo keeneysa in ay xannibayaan, daawooyinkan ayaa loo qeybiyaa laba kooxood oo waaweyn.
Xulasho (cardioselective) beta-blockers
Tallaabooyinka daroogooyinkaasi waa kuwo xaddidan oo loola jeedo in lagu xakameeyo xayawaanka β1-adrenergic (oo aan saameyn ku yeelanayn β2-reseptors), iyadoo inta badan saameynta wadnaha ee la arkay:
- hoos u dhac ku yimaada awoodda foosha wadnaha;
- dhimista garaaca wadnaha;
- xakameynta gudbinta iyada oo loo marayo habka atrio-ventricular;
- hoos u dhicin ee wadnaha.
Kooxdani waxaa ka mid ah daroogooyinka sida:
- Atenolol (Athenoben, Prinorm, Hypoten, Tenolol, iwm.);
- Bisoprolol (Concor, Bizomor, Coronale, Bisogamma, iwm.);
- betaxolol (Glaoks, Kerlon, Lokren, Betoptik, iwm.);
- metoprolol (Vazocardin, Betaloc, Corvitol, Logimax, iwm.);
- Nebivolol (Binelol, Nebilet, Nebivator);
- talinolol (Cordanum);
- esmolol (Breviblock).
Beta-xakameyn aan doorasho lahayn
Daawooyinkaas waxay awoodaan inay joojiyaan β1 iyo β2-adrenoreceptors labadaba, waxay leeyihiin antihypertensive, anti-xanaaq, antiarrhythmic iyo xayeysiinta xajinta. Daawooyinkaas waxay sidoo kale keenaan korodhka codka muusikada, habka arterioles, codka ilma-galeenka, iyo koritaanka caabuqa xididada dulinka ah.
Tani waxaa ka mid ah daawooyinka soo socda:
- propranolol (Anaprilin, Propamine, Noloten, Inderal, iwm.);
- bopindolol (Sandinorm);
- Levobunolol (Wistagen);
- nadolol (Korgard);
- Oxprenolol (Trazicor, Coretal);
- ovonol (Vistagan);
- pindolol (Vickin, Viscaldix);
- Sotalol (Sotagexal, Sotalex).
- timolol (akhriyey, Arutimol, Fotil, Glukomol, iwm.).
Beta-blockers of jiilkii ugu dambeeyey
Diyaargarowga cusub, sadexaad, jiilka waxaa lagu gartaa dhismooyin dheeri ah oo dheeri ah sababtoo ah xannibaadda alar-adrenergic reseptors. Liistada casriga casriga casriga ah waxaa ka mid ah:
- carvedilol (Acridilol, Vedicardol, Carvedigamma, Rekardium, iwm.);
- celiprolol (Tselipres);
- bucindolol
Si loo caddeeyo liiska daroogooyinka beta-blockers ee la yiraahdo tachycardia, waxaa habboon in la ogaado in kiiskan, daawooyinka ugu waxtarka badan ee gacan ka geysanaya in la yareeyo heerka wadnaha,
Contraindications ee isticmaalka beta-blockers
Diidmada ugu weyn ee daawooyinkaan waa:
- neefta neefta;
- cadaadiska dhiiga ee hooseeya;
- syndrome oo daciif ah ee nalka sanka;
- cudurada halbowlayaasha halbowlayaasha;
- bradycardia;
- naxdinta wadnaha ;
- block atrioventricular ee heerka labaad ama saddexaad.