Dawooyinka mukhaadiriga ah waa koox daawooyin ah oo ficil ahaan loogu talagalay in la joojiyo ama la joojiyo geeddi-socodka qaybta unugyada quwada iyo koritaanka unugyada isku xiran.
Goorma ayay calyadiyadu qoraan?
Meelaha ugu muhiimsan ee codsiga daawooyinka su'aasha ah waa daaweynta burooyinka malignantiga ah ee lagu gartey qaybta unugyada aan xakamayn (kansarka, leukemia , lymphomas, iwm.).
Si aad u yar, saameynta daroogada ee kooxdan waxay ku xiran tahay unugyada si degdeg ah u qaybsan ee lafaha lafaha, maqaarka, xuubka xuubka, epithelium ee mareenka caloosha. Tani waxay u oggolaaneysaa isticmaalka cytostatics sidoo kale cudurada ootimaalka (rheumatoid arthritis, scleroderma, lupus nephritis, cudurada fayoobaan, lupus erythematosus, iwm.).
Iyada oo qayb ka ah daaweynta isku dhafan, daawooyinka cytotoxic waxaa loo adeegsan karaa hadal ahaan qaabka kiniiniyada, kidharka, ama cirbadaha (xididada, xididada galmada, intralutinal, intravitreal). Muddada koorsada daaweynta waxaa lagu go'aamiyaa darnaanta cudurrada, waxtarka iyo dulqaadashada daroogada.
Liiska daawooyinka cytotoxic ah
Cytostatics waxaa lagu kala saaraa ujeedada amarka, iyo kala soociddani waa mid shuruudaysan, sababtoo ah daroogo badan oo ka mid ah koox isku mid ah ayaa leh qaab ficil ah oo ficil ahaan wax ku ool ah oo ka soo horjeeda noocyada kala duwan ee burooyinka malignantiga ah. Halkan waa liiska ugu muhiimsan ee magacyada daawooyinka cytotoxic:
1. Daroogooyinka alkilalka ah:
- alsilsulfonates (Busulfan, Treosulfan);
- Ethylenimines (Thiotepa);
- deriska ah ee nitrosoureas (Nimustine, Lomustine, Carmustine, Mystophoran, Streptozotocin);
- chloroethylamines (Chlorambucil, Ifosfamide, Bendamustine, Cyclophosphamide, Melphalan, Trophosphamide).
2. Alkaloids ka yimid asalka dhirta:
- podophyllotoxins (Teniposide, Etoposide);
- taxane (docetaxel, paclitaxel);
- sambabada (Vindesin, Vincristine, Vinblastine, Vinorelbine).
3. Antimetabolites:
- antagonists ee folic acid (Ralitrexed, Methotrexate);
- Nadiifiyeyaasha cirbadaha (Cladribine, Fludarabine, Pentostatin, Thioguanine);
- antagonists of pyrimidine (cytarabine, capecitabine, gemcitabine, fluorouracil).
4. Antibiyootikada leh waxqabadka antitumor:
- anthracyclines (Doxorubicin, Daunorubicin, Epirubicin, Idarubicin, Mitoxantrone);
- antibiyootikada kale ee antitumoral (mitomycin, bleomycin, plikamycin, dactinomycin).
5. Ciridka kale ee kale:
- Wareegyada xeryoodka (Irinotecan, Topotecan);
- derisyada platinum (Cisplatin, Carboplatin, Oxaliplatin);
- dadka kale (Temozolomide, Altrethamine, Estramustine, Amsacrine, L-asparaginase, Dacarbazine, Hydroxycarbamide, Procarbazine).
6. Isku-ilaalinta monoclonal (Trastuzumab, Ederkolomab, Rituximab).
7. Hormoodka Kansarka:
- antiandrogens (cyproterone acetate, bicalutamide, flutamide);
- progestins (Medroxyprogesterone acetate, Megestrol acetate);
- estrogens (Polyestradiol, Phosphastrol);
- antiestrogens (Toremifene, Tamoxifen, Droloxifene);
- xayawaanka aromatase (Anastrozol, Formestan, Exemestane).
- LH-RH agonists (Gocerelin, Buserelin, Leiprolein acetate, Tryptorelin).
Walxaha kudka ah ee loo yaqaan 'pankreatitis'
Cudurrada daran, cytostatics (sida, fluorouracil) ayaa loo isticmaali karaa daaweynta. Farsamooyinka ficilada daroogooyinkaasi waxay la xiriiraan awooddooda ay ku xakameynayaan shaqooyinka cakiran ee unugyada beedka.
Saameynada Waxyeellada ah ee Kontoroolka
Saameynada caadiga ah ee daaweynta cytostatics waa:
- timo lumis;
- shubanka;
- anorexia ;
- lallabbo;
- matag;
- madax xanuun;
- daciifinta murqaha;
- Ku xadgudubka caadada;
- dhalmo la'aanta;
- horumarinta xajiinta, iwm.